[6] Vitesse 2-1 Heracles Almelo [15] 2021-12-12 13:30
Stadium: Gelredome Round: 16
Referee: Jeroen Manschot Home Manager: Thomas Letsch Away Manager: Frank Wormuth
Head to Head
| Nederland - Eredivisie | 2021/01/09 19:00 | Heracles Almelo v Vitesse | W | 0-2 |
| Nederland - Eredivisie | 2020/10/03 14:30 | Vitesse v Heracles Almelo | W | 3-0 |
| KNVB Beker | 2020/01/22 17:30 | Heracles Almelo v Vitesse | W | 0-2 |
| Nederland - Eredivisie | 2019/08/24 17:45 | Heracles Almelo v Vitesse | D | 1-1 |
| Nederland - Eredivisie | 2019/03/16 19:45 | Heracles Almelo v Vitesse | L | 3-2 |
| KNVB Beker | 2018/10/31 17:30 | Heracles Almelo v Vitesse | W | 0-2 |
| Nederland - Eredivisie | 2018/10/07 12:30 | Vitesse v Heracles Almelo | W | 4-0 |
| Nederland - Eredivisie | 2018/03/17 18:45 | Vitesse v Heracles Almelo | D | 0-0 |
Home History
| UEFA Conference League | 2021/12/09 20:00 | Vitesse v NS Mura | W | 3-1 |
| Nederland - Eredivisie | 2021/12/04 17:45 | SC Cambuur Leeuwarden v Vitesse | W | 1-6 |
| Nederland - Eredivisie | 2021/11/28 19:00 | Vitesse v AZ | D | 0-0 |
| UEFA Conference League | 2021/11/25 17:45 | Rennes v Vitesse | D | 3-3 |
| Nederland - Eredivisie | 2021/11/20 15:30 | PSV v Vitesse | L | 2-0 |
| Nederland - Eredivisie | 2021/11/07 15:45 | Vitesse v FC Utrecht | W | 2-1 |
| UEFA Conference League | 2021/11/04 20:00 | Tottenham v Vitesse | L | 3-2 |
| Nederland - Eredivisie | 2021/10/30 18:00 | sc Heerenveen v Vitesse | W | 1-2 |
Away History
| Nederland - Eredivisie | 2021/12/04 20:00 | Heracles Almelo v sc Heerenveen | L | 0-1 |
| Nederland - Eredivisie | 2021/12/01 19:00 | Feyenoord v Heracles Almelo | L | 2-1 |
| Nederland - Eredivisie | 2021/11/28 13:30 | FC Utrecht v Heracles Almelo | L | 1-0 |
| Nederland - Eredivisie | 2021/11/20 20:00 | Heracles Almelo v Fortuna Sittard | W | 3-1 |
| Europa - Vriendschappelijke wedstrijden | 2021/11/11 13:00 | Fortuna Dusseldorf v Heracles Almelo | L | 2-1 |
| Nederland - Eredivisie | 2021/11/05 19:00 | FC Twente v Heracles Almelo | L | 1-0 |
| Nederland - Eredivisie | 2021/10/30 16:45 | Heracles Almelo v Ajax | D | 0-0 |
| KNVB Beker | 2021/10/26 18:00 | ASWH v Heracles Almelo | W | 1-3 |
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