Stadium: DakotaDome Round: 1
Home Manager: Bob Nielson Away Manager: John Stiegelmeier
| NCAAF | 2019/11/23 20:00 | South Dakota State v South Dakota | L | 21-24 |
| NCAAF FCS | 2018/11/17 20:00 | South Dakota v South Dakota State | W | 27-49 |
| NCAAF | 2017/11/18 20:00 | South Dakota v South Dakota State | W | 28-31 |
| NCAAF | 2021/11/06 19:00 | North Dakota State v South Dakota State | W | 19-27 |
| NCAAF | 2021/10/30 18:00 | South Dakota State v Youngstown State | W | 47-16 |
| NCAAF | 2021/10/23 19:00 | Northern Iowa v South Dakota State | L | 26-17 |
| NCAAF | 2021/10/16 17:00 | South Dakota State v Western Illinois | W | 41-17 |
| NCAAF | 2021/10/09 19:00 | SO Illinois v South Dakota State | L | 42-41 |
| NCAAF | 2021/10/02 23:00 | Utah Tech v South Dakota State | W | 7-55 |
| NCAAF | 2021/09/25 17:00 | South Dakota State v Indiana State | W | 44-0 |
| NCAAF | 2021/09/11 23:00 | South Dakota State v Lindenwood | W | 52-7 |
| NCAAF | 2021/11/06 17:00 | South Dakota v Western Illinois | W | 42-21 |
| NCAAF | 2021/10/23 18:00 | Illinois State v South Dakota | L | 20-14 |
| NCAAF | 2021/10/16 21:00 | South Dakota v Northern Iowa | W | 34-21 |
| NCAAF | 2021/10/09 19:00 | North Dakota v South Dakota | W | 13-20 |
| NCAAF | 2021/10/02 19:00 | Indiana State v South Dakota | W | 10-38 |
| NCAAF | 2021/09/26 00:00 | South Dakota v Missouri St | L | 23-31 |
| NCAAF | 2021/09/19 00:00 | South Dakota v Cal Poly | W | 48-14 |
| NCAAF | 2021/09/11 18:00 | Northern Arizona v South Dakota | W | 7-34 |