Round: 16
| El Salvador - Reserve league | 2022/02/06 18:00 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | D | 2-2 |
| El Salvador - Reserve league | 2021/11/18 17:00 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | L | 3-1 |
| El Salvador - Reserve league | 2021/09/16 21:00 | AD Isidro Metapan - Reserves v Once Deportivo de Ahuachapán - Reserves | D | 2-2 |
| El Salvador - Reserve league | 2021/03/10 18:30 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2021/02/18 18:45 | AD Isidro Metapan - Reserves v Once Deportivo de Ahuachapán - Reserves | W | 4-1 |
| El Salvador - Reserve league | 2020/02/26 18:02 | Once Deportivo de Ahuachapán - Reserves v AD Isidro Metapan - Reserves | W | 2-3 |
| El Salvador - Reserve league | 2022/04/03 17:00 | CD Platense Zacatecoluca - Reserves v AD Isidro Metapan - Reserves | L | 3-2 |
| El Salvador - Reserve league | 2022/03/23 21:00 | AD Isidro Metapan - Reserves v CD Luis Angel Firpo - Reserves | W | 2-1 |
| El Salvador - Reserve league | 2022/03/19 21:00 | AD Chalatenago - Reserves v AD Isidro Metapan - Reserves | D | 2-2 |
| El Salvador - Reserve league | 2022/03/12 21:00 | AD Isidro Metapan - Reserves v Alianza FC San Salvador - Reserves | L | 1-3 |
| El Salvador - Reserve league | 2022/03/05 17:00 | Atletico Marte - Reserves v AD Isidro Metapan - Reserves | W | 1-3 |
| El Salvador - Reserve league | 2022/02/26 21:00 | AD Isidro Metapan - Reserves v Municipal Limeno - Reserves | L | 0-1 |
| El Salvador - Reserve league | 2022/02/23 21:30 | Santa Tecla Reserves v AD Isidro Metapan - Reserves | L | 5-2 |
| El Salvador - Reserve league | 2022/02/19 21:00 | AD Isidro Metapan - Reserves v CD FAS - Reserves | W | 1-0 |
| El Salvador - Reserve league | 2022/04/03 17:00 | Once Deportivo de Ahuachapán - Reserves v Atletico Marte - Reserves | W | 1-0 |
| El Salvador - Reserve league | 2022/03/25 18:00 | Municipal Limeno - Reserves v Once Deportivo de Ahuachapán - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2022/03/19 18:30 | Once Deportivo de Ahuachapán - Reserves v Santa Tecla Reserves | D | 0-0 |
| El Salvador - Reserve league | 2022/03/05 18:30 | Jocoro FC - Reserves v Once Deportivo de Ahuachapán - Reserves | W | 1-2 |
| El Salvador - Reserve league | 2022/02/27 17:00 | Once Deportivo de Ahuachapán - Reserves v CD Aguila - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2022/02/23 17:00 | Once Deportivo de Ahuachapán - Reserves v Alianza FC San Salvador - Reserves | D | 1-1 |
| El Salvador - Reserve league | 2022/02/20 17:00 | CD Platense Zacatecoluca - Reserves v Once Deportivo de Ahuachapán - Reserves | L | 3-2 |
| El Salvador - Reserve league | 2022/02/13 18:00 | Once Deportivo de Ahuachapán - Reserves v CD Luis Angel Firpo - Reserves | L | 0-1 |