Stadium: Alamodome Round: 1
Home Manager: Jeff Traylor Away Manager: Dana Holgorsen
| NCAAF - Bowl-wedstrijden | 2021/12/28 17:00 | Houston v Auburn | W | 17-13 |
| NCAAF | 2021/12/04 21:00 | Houston v Cincinnati | L | 20-35 |
| NCAAF | 2021/11/27 17:00 | Houston v Connecticut | W | 45-17 |
| NCAAF | 2021/11/20 02:00 | Memphis v Houston | W | 13-31 |
| NCAAF | 2021/11/13 17:00 | Houston v Temple | W | 37-8 |
| NCAAF | 2021/11/06 23:30 | Houston v South Florida | W | 54-42 |
| NCAAF | 2021/10/30 23:00 | SMU v Houston | W | 37-44 |
| NCAAF | 2021/10/24 01:20 | East Carolina v Houston | W | 24-31 |
| NCAAF - Bowl-wedstrijden | 2021/12/22 00:30 | San Diego State v Texas-San Antonio | L | 38-24 |
| NCAAF | 2021/12/04 00:00 | Western Kentucky v Texas-San Antonio | W | 41-49 |
| NCAAF | 2021/11/27 19:00 | Texas-San Antonio v North Texas | L | 23-45 |
| NCAAF | 2021/11/20 20:30 | UAB v Texas-San Antonio | W | 31-34 |
| NCAAF | 2021/11/13 20:30 | Southern Mississippi v Texas-San Antonio | W | 17-27 |
| NCAAF | 2021/11/07 02:15 | Texas-San Antonio v UTEP | W | 44-23 |
| NCAAF | 2021/10/23 23:00 | Texas-San Antonio v Louisiana Tech | W | 45-16 |
| NCAAF | 2021/10/16 22:00 | Rice v Texas-San Antonio | W | 0-45 |