Stadium: Fitton Field Round: 1
Home Manager: Bob Chesney Away Manager: Tom Gilmore
| NCAAF | 2021/10/30 16:00 | Holy Cross v Lehigh | L | 31-12 |
| NCAAF | 2021/03/13 17:00 | Holy Cross v Lehigh | L | 20-3 |
| NCAAF | 2019/11/02 16:30 | Holy Cross v Lehigh | L | 24-17 |
| NCAAF | 2018/10/27 17:05 | Holy Cross v Lehigh | L | 56-0 |
| NCAAF | 2017/11/11 17:30 | Lehigh v Holy Cross | W | 34-21 |
| NCAAF | 2022/10/22 16:00 | Bucknell v Lehigh | L | 19-17 |
| NCAAF | 2022/10/15 17:00 | Lehigh v Cornell Big Red | L | 15-19 |
| NCAAF | 2022/10/08 16:00 | Fordham v Lehigh | L | 40-28 |
| NCAAF | 2022/10/01 16:00 | Monmouth v Lehigh | L | 35-7 |
| NCAAF | 2022/09/24 19:00 | Lehigh v Princeton | L | 17-29 |
| NCAAF | 2022/09/17 16:00 | Richmond v Lehigh | L | 30-6 |
| NCAAF | 2022/09/10 21:00 | Lehigh v Georgetown | W | 21-19 |
| NCAAF | 2022/09/02 22:00 | Lehigh v Villanova | L | 17-45 |
| NCAAF | 2022/10/29 17:00 | Fordham v Holy Cross | W | 52-53 |
| NCAAF | 2022/10/22 19:30 | Holy Cross v Lafayette | W | 24-21 |
| NCAAF | 2022/10/08 20:00 | Bucknell v Holy Cross | W | 0-57 |
| NCAAF | 2022/10/01 17:00 | Holy Cross v Harvard | W | 30-21 |
| NCAAF | 2022/09/24 17:00 | Holy Cross v Colgate | W | 35-10 |
| NCAAF | 2022/09/17 18:00 | Yale v Holy Cross | W | 14-38 |
| NCAAF | 2022/09/10 22:00 | Holy Cross v Buffalo | W | 37-31 |
| NCAAF | 2022/09/02 23:00 | Holy Cross v Merrimack | W | 31-17 |