Stadium: Bridgeforth Stadium/Zane Showker Field Round: 1
Home Manager: Curt Cignetti Away Manager: Dave Cecchini
| NCAAF | 2022/11/19 18:00 | Marist v Bucknell | W | 13-24 |
| NCAAF | 2022/11/12 17:30 | Bucknell v Georgetown | W | 24-21 |
| NCAAF | 2022/11/05 17:00 | Fordham v Bucknell | L | 59-17 |
| NCAAF | 2022/10/29 17:00 | Colgate v Bucknell | L | 13-7 |
| NCAAF | 2022/10/22 16:00 | Bucknell v Lehigh | W | 19-17 |
| NCAAF | 2022/10/15 16:00 | Bucknell v Yale | L | 9-29 |
| NCAAF | 2022/10/08 20:00 | Bucknell v Holy Cross | L | 0-57 |
| NCAAF | 2022/10/01 19:30 | Lafayette v Bucknell | L | 24-14 |
| NCAAF | 2022/11/26 17:00 | Coastal Carolina v James Madison | W | 7-47 |
| NCAAF | 2022/11/19 19:00 | Georgia State v James Madison | W | 40-42 |
| NCAAF | 2022/11/12 18:00 | James Madison v Old Dominion | W | 37-3 |
| NCAAF | 2022/11/05 23:30 | James Madison v Louisville | L | 10-34 |
| NCAAF | 2022/10/22 19:30 | Marshall v James Madison | L | 26-12 |
| NCAAF | 2022/10/15 20:00 | James Madison v Georgia Southern | L | 38-45 |
| NCAAF | 2022/10/08 23:00 | James Madison v Arkansas State | W | 42-20 |
| NCAAF | 2022/10/01 17:30 | Texas State v James Madison | W | 13-40 |