[7] Spartak Moskou 2-1 Lokomotiv Moskou [4] 2018-12-02 16:00
Stadium: Otkritie Arena Round: 16
Referee: Sergey Gennadyevich Karasev Home Manager: Oleg Kononov Away Manager: Yury Semin
Head to Head
| Rusland - Premier League | 2018/08/04 16:00 | Lokomotiv Moskou v Spartak Moskou | D | 0-0 |
| Rusland - Premier League | 2018/03/04 13:30 | Lokomotiv Moskou v Spartak Moskou | D | 0-0 |
| Rusland - Premier League | 2017/08/19 14:30 | Spartak Moskou v Lokomotiv Moskou | L | 3-4 |
| Rusland - Supercup | 2017/07/14 18:30 | Lokomotiv Moskou v Spartak Moskou | W | 1-2 |
| Rusland - Premier League | 2017/03/18 13:30 | Lokomotiv Moskou v Spartak Moskou | D | 1-1 |
| Rusland - Premier League | 2016/09/11 13:30 | Spartak Moskou v Lokomotiv Moskou | W | 1-0 |
| Rusland - Premier League | 2016/04/30 16:30 | Lokomotiv Moskou v Spartak Moskou | W | 0-2 |
| Rusland - Premier League | 2015/10/18 10:30 | Spartak Moskou v Lokomotiv Moskou | L | 1-2 |
Home History
| UEFA Europa League | 2018/11/29 15:50 | Spartak Moskou v Rapid Wien | L | 1-2 |
| Rusland - Premier League | 2018/11/25 11:00 | Spartak Moskou v Krylia Sovetov | W | 3-1 |
| Rusland - Premier League | 2018/11/11 11:00 | FC Ufa v Spartak Moskou | L | 2-0 |
| UEFA Europa League | 2018/11/08 17:55 | Spartak Moskou v Rangers | W | 4-3 |
| Rusland - Premier League | 2018/11/04 16:00 | Spartak Moskou v Ural | L | 1-2 |
| Rusland - Beker | 2018/11/01 17:00 | Spartak Moskou v Anzhi Makhachkala | W | 1-0 |
| Rusland - Premier League | 2018/10/29 17:30 | Rubin Kazan v Spartak Moskou | D | 1-1 |
| UEFA Europa League | 2018/10/25 19:00 | Rangers v Spartak Moskou | D | 0-0 |
Away History
| UEFA Champions League | 2018/11/28 17:55 | Lokomotiv Moskou v Galatasaray SK | W | 2-0 |
| Rusland - Premier League | 2018/11/23 17:30 | Lokomotiv Moskou v Ural | L | 1-2 |
| Rusland - Premier League | 2018/11/11 13:30 | Rubin Kazan v Lokomotiv Moskou | D | 0-0 |
| UEFA Champions League | 2018/11/06 20:00 | FC Porto v Lokomotiv Moskou | L | 4-1 |
| Rusland - Premier League | 2018/11/03 11:00 | Lokomotiv Moskou v Arsenal Tula | W | 3-1 |
| Rusland - Beker | 2018/10/31 16:30 | Lokomotiv Moskou v FK Yenisey | W | 4-1 |
| Rusland - Premier League | 2018/10/28 11:00 | FK Yenisey v Lokomotiv Moskou | W | 0-3 |
| UEFA Champions League | 2018/10/24 19:00 | Lokomotiv Moskou v FC Porto | L | 1-3 |
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