| NCAAF | 11/11 20:00 | 1 | Missouri Southern Lions v Missouri Western Griffons | W | 47-41 | |
| NCAAF | 11/04 18:00 | 1 | Emporia State v Missouri Southern Lions | L | 63-28 | |
| NCAAF | 10/28 19:00 | 1 | Missouri Southern Lions v Central Missouri Mules | L | 21-42 | |
| NCAAF | 10/21 19:00 | 1 | Blue Tigers v Missouri Southern Lions | W | 5-63 | |
| NCAAF | 10/14 19:00 | 1 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 21-31 | |
| NCAAF | 10/07 19:00 | 1 | Missouri Southern Lions v Fort Hays State University Tigers | L | 22-35 | |
| NCAAF | 09/30 19:00 | 1 | Central Oklahoma v Missouri Southern Lions | L | 30-27 | |
| NCAAF | 09/23 19:00 | 1 | Missouri Southern Lions v Northeastern State Riverhawks | W | 42-0 | |
| NCAAF | 09/16 17:00 | 1 | Nebraska Kearney v Missouri Southern Lions | W | 13-18 | |
| NCAAF | 09/07 23:00 | 1 | Washburn Ichabods Football v Missouri Southern Lions | W | 23-30 | |
| NCAAF | 09/01 00:00 | 1 | Missouri Southern Lions v NW Missouri State | L | 24-31 | |
| NCAAF | 11/12 20:00 | 1 | Missouri Southern Lions v Washburn Ichabods Football | L | 20-37 | |
| NCAAF | 11/05 18:30 | 1 | NW Missouri State v Missouri Southern Lions | L | 27-5 | |
| NCAAF | 10/29 18:00 | 1 | Missouri Western Griffons v Missouri Southern Lions | L | 31-27 | |
| NCAAF | 10/22 19:00 | 1 | Missouri Southern Lions v Emporia State | L | 21-24 | |
| NCAAF | 10/15 18:30 | 1 | Central Missouri Mules v Missouri Southern Lions | L | 20-17 | |
| NCAAF | 10/08 19:00 | 1 | Missouri Southern Lions v Blue Tigers | W | 37-14 | |
| NCAAF | 10/01 19:00 | 1 | Pittsburgh State Gorillas v Missouri Southern Lions | L | 38-9 | |
| NCAAF | 09/25 00:00 | 1 | Fort Hays State University Tigers v Missouri Southern Lions | W | 24-25 | |
| NCAAF | 09/17 22:00 | 1 | Missouri Southern Lions v Central Oklahoma | W | 40-21 | |
| NCAAF | 09/10 23:00 | 1 | Northeastern State Riverhawks v Missouri Southern Lions | W | 13-30 | |
| NCAAF | 09/02 00:00 | 1 | Missouri Southern Lions v Nebraska Kearney | L | 7-24 | |
| NCAAF | 11/13 19:00 | 1 | Washburn Ichabods Football v Missouri Southern Lions | L | 38-28 | |
| NCAAF | 11/06 19:00 | 1 | Missouri Southern Lions v NW Missouri State | L | 7-49 | |
| NCAAF | 10/30 19:00 | 1 | Missouri Southern Lions v Missouri Western Griffons | L | 28-45 | |
| NCAAF | 10/23 19:00 | 1 | Emporia State v Missouri Southern Lions | L | 24-21 | |
| NCAAF | 10/16 21:00 | 1 | Missouri Southern Lions v Central Missouri Mules | W | 30-28 | |
| NCAAF | 10/09 19:00 | 1 | Blue Tigers v Missouri Southern Lions | W | 32-52 | |
| NCAAF | 10/02 19:00 | 1 | Missouri Southern Lions v Pittsburgh State Gorillas | L | 16-20 | |
| NCAAF | 09/25 19:00 | 1 | Missouri Southern Lions v Fort Hays State University Tigers | L | 21-42 |