Stadium: Saluki Stadium Round: 1
Home Manager: Nick Hill Away Manager: Ryan Beard
| NCAAF | 2022/10/08 19:00 | SO Illinois v Missouri St | L | 38-21 |
| NCAAF | 2021/11/06 17:00 | Missouri St v SO Illinois | W | 38-28 |
| NCAAF | 2021/03/27 19:00 | SO Illinois v Missouri St | W | 27-30 |
| NCAAF | 2019/11/09 20:00 | Missouri St v SO Illinois | L | 14-37 |
| NCAAF | 2018/10/27 19:00 | Missouri St v SO Illinois | L | 35-49 |
| NCAAF | 2017/11/04 18:00 | SO Illinois v Missouri St | W | 28-36 |
| NCAAF | 2023/09/23 19:00 | Utah Tech v Missouri St | W | 14-59 |
| NCAAF | 2023/09/09 23:00 | Missouri St v Tennessee Martin | L | 31-38 |
| NCAAF | 2023/09/02 00:00 | Missouri St v Kansas | L | 17-48 |
| NCAAF | 2022/11/19 18:00 | Missouri St v Indiana State | W | 24-7 |
| NCAAF | 2022/11/12 20:00 | Youngstown State v Missouri St | W | 22-25 |
| NCAAF | 2022/11/05 18:00 | Missouri St v South Dakota | L | 13-20 |
| NCAAF | 2022/10/29 19:00 | Western Illinois v Missouri St | W | 14-64 |
| NCAAF | 2022/10/22 21:00 | Missouri St v Northern Iowa | L | 20-41 |
| NCAAF | 2023/09/16 23:00 | SO Illinois v SE Missouri St | W | 26-25 |
| NCAAF | 2023/09/09 19:30 | SO Illinois v Northern Illinois | W | 14-11 |
| NCAAF | 2023/09/02 23:00 | Austin Peay v SO Illinois | W | 23-49 |
| NCAAF | 2022/11/19 17:00 | SO Illinois v Youngstown State | L | 21-28 |
| NCAAF | 2022/11/12 19:00 | North Dakota State v SO Illinois | L | 21-18 |
| NCAAF | 2022/10/29 19:00 | Northern Iowa v SO Illinois | L | 37-36 |
| NCAAF | 2022/10/22 19:00 | SO Illinois v South Dakota | L | 24-27 |
| NCAAF | 2022/10/15 19:00 | Western Illinois v SO Illinois | W | 7-30 |